2. Look for big problems to solve
The healthcare industry has no shortage of big problems to throw at AI: access, navigation, burnout, administrative burden, care variation, chronic disease, population health, persistent disparities. These are the problems we’ve been talking about for years precisely because they’re hard (and most worth solving).
The more enticing path, of course, is to focus on near-term, incremental gains. Save a few minutes here and automate a task there. Make an existing workflow slightly less painful. There’s value in that, especially in an industry where time is perpetually scarce. But if that’s where AI begins and ends, we may wind up paying many of the technology’s costs without capturing its promise. There also is a risk of saving time through single-use cases, but passing bottlenecks or inefficiencies downstream.
The more important opportunity is to use AI to make headway on problems that have resisted every other solution we’ve tried. Take Google’s AMIE, developed for clinical history-taking and diagnostic dialogue, which has evolved beyond answering clinical questions to synthesizing patient histories and multimodal data, reasoning through diagnostic uncertainty, engaging patients in dynamic conversations, and supporting clinical decisions across the care journey. Or Stanford Medicine’s SleepFM, an AI model that can predict future risk for more than 100 health conditions using data collected during a single night’s sleep. Or Mayo Clinic’s AI-assisted phlebotomy system, a model intended to help mobile care teams perform blood draws in high-need rural communities by identifying optimal veins and guiding needle placement in real time. Or the emergence of self-driving laboratories that combine AI, robotics, and autonomous experimentation to accelerate the discovery of new medicines.
These examples represent only a fraction of what may be possible. AI could expand access to primary care in underserved communities, help identify disease before symptoms emerge, guide patients to the right care at the right time, and help healthcare leaders make better strategic investment decisions through increasingly sophisticated simulations.
Of course, thinking bigger only works if your technology partners can think bigger with you. Challenge your partners and vendors to understand the problem you’re trying to solve and demonstrate how their technology will move the needle. Choose the outcome and evaluate the end-to-end domain or process(es) to target. Then select the technology (and partner) best equipped to deliver it.
Three essential questions for leaders
- Does the revised process create a genuinely new or better capability, or does it primarily make an existing process faster?
- What operational, clinical, or organizational changes must accompany the technology so that adoption can materially improve outcomes?
- What governance and/or security access protocols are necessary to protect the organization, as well as maintain the AI solution?
3. Weigh internal benefits along with potential externalities
A tool might reduce administrative expense while also eliminating jobs. It might improve clinical decision support while introducing new opportunities for bias or overreliance. It might make a workflow more scalable while increasing dependence on energy- and resource-intensive infrastructure.
Some of those tradeoffs are relatively easy to put a number on. Others aren’t. But just because an impact is harder to quantify doesn’t mean it isn’t real.
Health systems are more than businesses; they’re stewards of community resources and health. If part of the mission is to improve the health and well-being of the communities you serve, then it’s hard to argue that the effects of your technology decisions on those same communities should sit outside the business case.
Ask who benefits? Who accepts the risk? What happens when technology gets it wrong? Could it deepen an existing disparity? And are the benefits meaningful enough to justify the disruption required to get them?
As with any new technology, AI hype may lead organizations to aimlessly execute AI for the sake of AI. This approach can create confusion, encourage organizations to focus on smaller initiatives, and introduce unnecessary cost and risk. A common indicator is the inability to move from pilot projects to scaled implementation—or a tendency to build individual use cases instead of reimagining the broader processes they are intended to improve.
Three essential questions for leaders
- Who benefits from this deployment, who bears the risk, and does said benefit outweigh the risk of execution?
- What important consequences are missing from the traditional business case?
- Is the deployment exploratory, use-case oriented, or geared toward end-to-end process?

4. Measure impact and effectiveness
One of the biggest risks inherent in AI is mistaking adoption for progress.
That necessitates measuring AI at two levels. First, is it working? Is it accurate, reliable, usable, and helping (rather than complicating) the workflow? Look for time saved associated with token cost; accuracy measures associated with drift and maintenance cost; and adoption metrics associated with user access.
Then comes the more important question: Did it solve the problem we paid it to solve? If the goal was better access, did more patients get care? If it was less burnout, are clinicians actually less burned out? If it was more capacity, did we do anything meaningful with that capacity?
Those answers shouldn’t be reverse-engineered after launch. Define success upfront, decide how you’ll measure it, and be equally clear about what would make you change course. There’s no prize for keeping an AI tool alive simply because it was exciting enough to announce six months ago. In fact, one key commonality we’ve observed among health systems reaping the most return on investment is the willingness to sunset projects that lead to diminishing returns.
“Did the AI solution work?” is probably the wrong question. The better one is: “Did it make anything that matters meaningfully better?”
Three essential questions for leaders
- What outcome are we trying to change, how will we know if we changed it, and are we focusing on quantitative metrics that can be tracked and traced post deployment?
- What feedback loop have we accounted for that can provide evidence based on users, as well as the technical performance?
- What evidence would cause us to modify, scale back, or stop using the tool?
Where technology meets leadership
Maybe being an “apocaloptimist” isn’t such a bad place to land. You can believe deeply in AI’s potential while also being clear-eyed about its costs. Healthcare may in fact need both instincts at once: enough optimism to pursue what’s possible, and enough skepticism to make sure what’s possible is worth pursuing.
That requires thinking beyond adoption for adoption’s sake: Establish the discipline to know where AI belongs, aim it at problems worth solving, look beyond short-term ROI, and measure whether it’s working and if key success metrics improved.
For all the sophistication of the technology, the hardest questions AI raises are still distinctly human ones: What do we value? Who benefits? Who bears the cost? And what kind of healthcare system are we ultimately trying to build?
AI can help us answer many questions. Those, however, are still ours.